Invariant surface glycoprotein 65 of Trypanosoma brucei is a complement C3 receptor

Invariant surface glycoprotein 65 of Trypanosoma brucei is a complement C3 receptor

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Trypanosomes evade the immune response through antigenic variation of a surface coat containing variant surface glycoproteins (VSG).They also express invariant surface glycoproteins (ISGs), which are less well understood.Here, Macleod Telescopic Hood et al.show that ISG65 of T.

brucei is a receptor for complement component 3.They provide the crystal structure of T.brucei ISG65 in complex with complement C3d and show evidence that ISG65 is involved in reducing trypanosome susceptibility to C3-mediated Covers clearance in vivo.